That is the prediction of BBC Sport pundit and former Manchester United defender Phil Neville.
Ronaldo helped Portugal draw 3-3 with Spain in their opening game of the 2018 World Cup.
The 33-year-old struck an unstoppable free kick in the closing stages to steal a point for his side.
Today is the turn of Lionel Messi to make his bow at this year’s tournament.
He will captain Argentina against Iceland (2pm) in what could be his final ever World Cup.
And Neville reckons he will want to get one over old Real Madrid rival Cristiano Ronaldo.
“He’ll score four tonight, Messi,” Neville said.
“That’s how he’s been for the last 15 years.
“He will want to win a World Cup, so will Cristiano.
“But there’s that little bit inside them that will want the individual glory.
“Last night would have fired Messi up to go out there to score goals.”