The four-time MVP missed 17 straight games for the Lakers due to a groin strain sustained on Christmas Day before returning in a 123-120 overtime win over the LA Clippers last week.
LeBron had 24 points, 14 rebounds and nine assists in the Lakers’ win.
But after playing 40 minutes on his return, the 34-year-old opted not to face Golden State with Luke Walton admitting his superstar was “pretty sore” the next day.
The Lakers had done 6-11 in LeBron’s absence and also lost by 14 to the Warriors, a record which sees them down in 10th in the Western Conference.
They can go back to within a game of the Clippers – who occupy eighth spot – with a win against Indiana, but would hold a 27-27 record if they are beaten.
But the good news for the Lakers is that they will have LeBron back in their rotation against the Pacers (4pm PST/midnight UK).
LeBron will not be under a minutes restriction but head coach Walton is keen to ensure he does not over-load the forward and will look to manage him carefully.
He will start the game alongside Brandon Ingram, Rajon Rondo, Kyle Kuzma and Ivica Zubac.
The Lakers leader said: “I’m looking forward to getting back out there with the guys tonight.”
LeBron has averaged 27.2 points, 8.5 rebounds and 7.2 assists per game so far this year.
Big man Zubac, meanwhile, is playing through an avulsion fracture in his left middle finger.
The 21-year-old has been a major part of the Lakers’ team recently and has started all of their last six games.
Meanwhile, since losing Victor Oladipo to a season-ending injury the Pacers have gone 2-4.
Despite that run, they are still fourth in the Eastern Conference and level with the Boston Celtics.
In the previous contest between the two teams this year, the Lakers won 104-96 at Staples Center in November with LeBron dropping 38 points.
Off the field, L.A. are dominated by trade talks at the moment, particularly concerning Anthony Davis.
The latest is that the Lakers’ pursuit of the New Orleans Pelicans’ six-time All-Star will have to wait until the offseason because the Pelicans are demanding too much to do a deal now.