Local media reported that 198 flights have been cancelled in Japan, mostly those to and from Naha Airport, which is located in the southern state of Okinawa.
The typhoon is currently a Category 2 storm, but could strengthen to Category 3 before hitting Japan over the weekend.
Kristina Pydynowski, AccuWeather senior meteorologist, commented on the threat, saying: “Trami remains on track to blast the Ryukyu Islands Friday night into Sunday morning, with mainland Japan bracing for the blow Sunday into Monday.
“Time is running out for preparations in the Ryukyu Islands.
“These islands are expected to be slammed with destructive wind gusts of 100-140 miles per hour and flooding rain.
“Dangerous seas building to heights in excess of 10 metres can severely flood coastal communities.”
The eye of the storm is forecast to pass just west of the Ryukyu Islands on Friday, while landfall on mainland Japan is expected to occur on Sunday morning.
If the storm does make landfall on mainland Japan, it will be the fifth to do so since July.
The most severe conditions will be felt throughout the Ryukyu Islands, southern Kyushu, Shikoku, and southern Honshu.
As of 3am, local time on Friday morning (7pm BST), the storm was located 249 miles south-east of Miyako-jima island in Okinawa.
Winds in the eye of the storm have reached 100 miles per hour according to the Japan Meteorological Agency, threatening to cause dangerous storm surges throughout coastal communities.
Ms Pydynowski warned: “Storm surge flooding along the entire southern coast of Japan will further threaten lives and property Sunday into Sunday night.
“Anyone outside during the height of the storm can endure bodily harm or be fatally struck by flying debris.”
The heaviest rain will occur throughout Saturday and Sunday, with between six to 12 inches of rain forecast across large parts of southern Japan.
Up to 19.6 inches of rain are also expected in isolated regions.
Conditions are then expected to return largely to normal as the typhoon passes Japan throughout Monday.
Typhoon Trami follows soon after Typhoon Jebi struck the mainland at the start of September, killing a total of 17 people.
Jebi was the strongest storm to hit the mainland in 25 years.